tuning
Mentors and Regional Facilitators
| Name | Region | Skills | Interests |
|---|---|---|---|
| David Liu | CCMNet | ||
| Jason Wells | ACCESS CSSN, Campus Champions | ||
| Justin Oelgoetz | Campus Champions, CCMNet | ||
| Paul Rulis | Campus Champions | ||
| Ron Rahaman | Campus Champions | ||
| Shaohao Chen | Northeast | ||
| Liwen Shih | Campus Champions, ACCESS CSSN, CCMNet | ||
| Seung Woo Son | Northeast |
Affinity Groups
There are no Affinity Groups associated with this topic. View All Affinity Groups.
Announcements
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Upcoming Events & Trainings
| Title | Date |
|---|---|
| HPC & Data Science Summer Institute 2025 | 8/04/25 |
| HPC & Data Science Summer Institute 2025 | 8/04/25 |
| HPC & Data Science Summer Institute 2025 | 8/04/25 |
Topics from Ask.CI
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Fine-tuning LLMs with PEFT and LoRA | Video | faster, optimization, performance-tuning, tuning | Intermediate, Advanced |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
David Liu
Purdue University
Programs
CCMNet
Roles
mentor, researcher/educator, research computing facilitator, CCMNet
Expertise
Expertise
Expertise
People with Interest
Interests
Wirawan Purwanto
Old Dominion University
Programs
Campus Champions, Northeast, ACCESS CSSN
Roles
mentor, research computing facilitator, cssn
Interests
Paul Rulis
University of Missouri-Kansas City
Programs
Campus Champions
Roles
researcher/educator, research computing facilitator
