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Title Category Tags Skill Level
Fine-tuning LLMs with PEFT and LoRA Video faster, optimization, performance-tuning, tuning Intermediate, Advanced

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Seung Woo Son

University of Massachusetts Lowell

Programs

Northeast

Roles

mentor

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Expertise

Liwen Shih

University of Houston-Clear Lake

Programs

Campus Champions, ACCESS CSSN, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, cssn, CCMNet

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Expertise

Ying-Chih Sun

Harrisburg University

Programs

CAREERS

Roles

student-facilitator

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Expertise

People with Interest

Justin Oelgoetz

Austin Peay State University

Programs

Campus Champions, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, CCMNet

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Interests

Widodo Samyono

Jarvis Christian College

Programs

Campus Champions, CCMNet

Roles

researcher/educator, research computing facilitator, CCMNet

Widodo Samyono, PhD in Computational and Applied Mathematics

Interests

Daniel Benedict

Texas Tech University

Programs

CCMNet

Roles

mentor, ci systems engineer, CCMNet

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Interests