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Mentors and Regional Facilitators
Name Region Skills Interests
Anita Schwartz Campus Champions
Michael Blackmon Campus Champions, ACCESS CSSN
Brian Haymore Campus Champions, RMACC, CCMNet
Kevin Bryan Campus Champions
Christina Divoll Campus Champions, ACCESS CSSN
Cody Stevens Campus Champions, CCMNet
David Liu CCMNet
Yu-Chieh Chi Campus Champions
Jordan Hayes Campus Champions
Juan Vanegas Northeast
Kali McLennan Campus Champions, Great Plains
Katherine Nelson Campus Champions, CAREERS, ACCESS CSSN
James Hutcheson Campus Champions, ACCESS CSSN
Justin Oelgoetz Campus Champions, CCMNet
Paul Rulis Campus Champions
David Reddy Campus Champions
Ric Anderson Campus Champions
Ruben Lara Campus Champions
Steven Kuhlo TRECIS
Sathish Srinivasan ACCESS CSSN
Trey Breckenridge Campus Champions

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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Calloway Sutton

Indiana University

Programs

ACCESS CSSN

Roles

cssn

Placeholder headshot

Expertise

David Reddy

University of South Carolina

Programs

Campus Champions

Roles

research computing facilitator, Affinity Group Leader

Placeholder headshot

Expertise

c
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Kevin Bryan

University of Rhode Island

Programs

Campus Champions

Roles

research computing facilitator

Placeholder headshot

Expertise

c
+38 more tags

People with Interest

Lenore Martin

University of Rhoide Island

Programs

CAREERS

Roles

researcher/educator

Lenore in office

Interests

Devin Bayly

University of Arizona

Programs

ACCESS CSSN, Campus Champions, CCMNet

Roles

research computing facilitator, Affinity Group Leader, CCMNet

User

Interests

David Warden

SUNY Geneseo

Programs

Campus Champions, CCMNet, ACCESS CSSN

Roles

research computing facilitator, cssn, CCMNet

black and white analog photo print portrait of David Warden in a darkroom processing tray

Interests